Manchester United have suffered a blow in defence after Luke Shaw was ruled out of the derby against Man City.
Shaw also missed the win over Champions League win over Sabah on Thursday.
There are three changes in all from that Champions League clash, with Diogo Dalot and Harry Maguire coming in for Noussair Mazraoui and Leny Yoro.
Marcus Rashford also returns to the starting line-up in place of Benjamin Sesko.
Manchester City boss, Enzo Maresca, made just one change from Tuesday’s Champions League win in Porto.
Elliot Anderson replaces youngster Ayyoub Bouaddi. Phil Foden and Rayan Cherki both start, while Iliman Ndiaye and Nico O’Reilly are on the bench.
Man Utd XI: Lammens, Dalot, Maguire, Martinez, Dorgu, Tielemans, Mainoo, Mbeumo, Cunha, Fernandes, Rashford.
Man City XI: Donnarumma, Nunes, Dias, Guehi, Gvardiol, Anderson, Fernandez, Foden, Semenyo, Cherki, Haaland.
